The real mechanism of the Skraup � Doebner � Von Miller quinoline synthesis remains controversial and not well understood despite several mechanistic studies reported on the matter. A series of unexpected cycloalkenylated-dihydroquinoline derivatives have been obtained through the Skraup � Doebner � Von Miller quinoline synthesis. On the basis of these unexpected results and in agreement with some of the previously reported quinolines synthesis, an alternative mechanistic pathway is proposed for this variance of the reaction. We are discussing this newly proposed mechanistic pathway in this presentation.

Skraup - Doebner - Von Miller quinoline synthesis: An alternative mechanistic pathway

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.