This research involves synthesizing a small trefoil knot and the first ever small-molecule Figure Eight knot.  Our Thread-Link-Cut (T-L-C) approach involves an electron-rich host molecule binding an electron-poor guest molecule(s). Synthetic progress towards several Guests will be presented. One Guest (1  ) has been successfully synthesized in five steps (32%). Synthesis of the first generation Host (2  , R= H) will be discussed.  Second generation Hosts contain solubilizing groups (R) to aid T-L-C experiments. 

Synthesis of host and guest molecules for knot preparation using the thread-link-cut method

243rd National Meeting (2012)

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