Adenylate kinase (EC 2.7.4.3) senses cellular energetic imbalances and modulated cellular, interstitial and blood AMP levels. There is a direct relationship between defects in adenylate kinase and AMP metabolic signaling and human diseases. Novel binding materials for adenylate kinase (AdK) were thus constructed using six pentadecapeptides as templates to fabricate molecularly imprinted polymers (MIPs) on QCM chip. Although the infrastructure of each molecularly imprinted cavity is different, AdK was captured in the complementary cavity with different conformations. The binding ability of AdK with each MIPs chip was recorded and the use of these materials as a tool to explore protein function will be demonstated.

Adenylate kinase recognition using peptide imprinted QCM chip

243rd National Meeting (2012)

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