Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes, and by thermal processing of food such as baking and frying. AGEs and especially CML has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate, which allows for future incorporation of CML in peptide chains.

Convenient synthesis of CML, a key advanced glycation endproduct (AGE) biomarker

243rd National Meeting (2012)

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