The successful development of new synthetic methods and catalysts will have an impact on the discovery and production of chiral organic molecules and materials. Our goal is to develop catalysts and synthetic methodology that minimize the use of reagents and organic solvents, increase efficiency, and approach 100% selectivity.  We are investigating the activity and selectivity of various catalyst systems, including scandium- and indium-based chiral Lewis acids, Bronsted acids, and a new class of silanediol hydrogen-bonding catalysts. Applications of these catalysts for carbon-carbon bond-forming reactions and the enantioselective synthesis of complex molecules such as spirooxindoles will be presented. This lecture will also discuss mechanism and molecular insights for catalyst activity and design.

Asymmetric catalysis and molecular design inspired by spirooxindoles and silanediols

243rd National Meeting (2012)

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