The degradation of active pharmaceutical ingredients (API) found in the environment is becoming more important. In this study, we are investigating the conversion of methyl amines to ketones through the use of the TAML activators. TAML catalysts are hydrogen peroxide activators and can be used for oxidative transformations. A secondary aliphatic amine moiety based on Sertaline (a component of the antidepressant Zoloft�) is used in this work as a model compound to study this conversion. In this study we investigated the experimental variables of pH, time, catalyst concentration, and peroxide concentration in order to obtain the highest yields of the ketone product. The reaction was monitored using high pressure liquid chromatography (HPLC).

Optimizing the use of the Fe<sup>III</sup>-TAML system for a methyl-amine to ketone conversion

243rd National Meeting (2012)

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Optimizing the use of the FeIII-TAML system for a methyl-amine to ketone conversion

Optimizing the use of the Fe^III-TAML system for a methyl-amine to ketone conversion