Utilizing a scanning electrochemical microscope (SECM), past studies have shown that ultra micro electrodes (UME's) using a pulled capillary tube could readily measure silver ion concentrations near the surface of a living cell.  A UME electrode is being developed to measure copper ions near the surfaces of cells so it can be used to investigate the toxic mechanism of copper in bacteria.  This part of the electrode development focuses on optimizing the right combination of solvent (likely DCE), electrolyte, and copper selective ionophore for use in the UME capillary.  Several different copper ionophores, with DCE and a hydrophobic electrolyte will be mixed at different concentrations to optimize sensitivity of response to copper ion, and to test for possible interference from other likely cations.  In the future, this UME will hopefully be used to study the development of bacterial resistance to copper.

Development of chemistry in dichloroethane for an ITIES based ultra micro ion selective electrode (UME/ITIES) for copper

243rd National Meeting (2012)

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