Limits on non-target tissue exposure and avoidance of metabolic changes to active agents make topical application/delivery of skin active agents highly desirable.  Individually, phospholipid liposomes and polyamidoamine dendrimers are effective delivery systems of various active agents.  Potentially, combining the two delivery systems for topical application would maximize efficacy of skin active agents.  However, it is not fully understood how the two systems interaction with one another.In our current work, we used fluorescence leakage measurements and a quartz crystal microbalance with dissipation monitoring to investigate the interaction of carboxyl-terminated dendrimers of two different sizes with 1-palmitoyl-2-oleoyl phosphocholine bilayers.  Fluorescence leakage measurements demonstrate that smaller dendrimer disturbs the membrane bilayer such that leakage increased with dendrimers concentration and the larger dendrimer actually stabilized vesicles against leakage.   QCMD measurements indicate weak binding for the smaller dendrimers.

G2 and G5 Carboxyl-terminated polyamidoamine dendrimers interact differently with 1-palmitoyl-2-oleoyl phosphocholine bilayers

243rd National Meeting (2012)

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