Currently, the pharmaceutical industry mainly depends on crystalline active pharmaceutical ingredients (APIs).  Unfortunately, many of such drugs fail to pass testing due to issues with delivery mechanisms such as dissolution, transport, bioavailability, and poor control over polymorphism.  Some years ago, we proposed strategies based on ionic liquids (ILs) as APIs to impart new or enhanced properties into existing APIs.  The API-ILs synthesized from pharmaceutical ingredient salts not only retain pharmaceutical activity but also have the added benefits of existing in a liquid form.  Herein, we will discuss the transport ability of some API-ILs through artificial silicon membrane and compare it with that of the starting materials used for the synthesis of API-ILs.

Membrane transport of active pharmaceutical ingredient-based ionic liquids

243rd National Meeting (2012)

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