The advent of economical, facile and reliable synthetic methodologies has always been central to synthesis of intricate architecture of natural products, pharmaceutical candidates or polymers as well as libraries of structural analogs of biologically active scaffolds with improved activity profile and drug-ability. Our research interests include development of new synthetic methodologies like1 1) orthogonal protection and glycosylation strategies for sugars, 2) synthesis and biocatalytic kinetic resolution of important drugs/intermediates such as beta-lactams and vic-amino alcohols, 3) enzymatic separation of geometrical isomers, 4) asymmetric organocatalytic strategies. Moreover our emphasis is also on generation of natural product based libraries by isolation and structural modifications.2 Certain leads with improved/potent activity than natural counterparts have been identified and taken forward as potential therapeutics for treatment of cancer and infection.

Development of synthetic methodologies and their application in drug discovery

243rd National Meeting (2012)

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