In this talk, we present our recent work on the synthesis of a third generation PEO-based dendrimer containing triazole units prepared divergently on grams scale through metal-free Huisgen 1,3-dipolar cycloaddition ('click') reaction between activated disubstituted alkyne and terminal azide groups. Synthetic efforts leading to the optimized and efficient route are presented. The growth of the dendrimers was achieved in high yield without purification. The presence of PEO and triazole units makes this dendrimer a very promising material for bio-related applications. Structural variations at the core and periphery of the dendrimer are underway in our laboratory and the results will be presented. Finally, toxicity studies as a function of generation, core and nature of termini will be discussed as well.

Efficient and rapid divergent synthesis of PEO-based dendrimers through catalyst-free click chemistry

243rd National Meeting (2012)

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