Cocoa has increasingly attracted attention due to its biological properties. The objective was to investigate the effects of cocoa feeding against N-nitrosodiethylamine (DEN)-induced liver injury in rats. Male rats were divided into five groups. Groups 1 and 2 were fed with standard and cocoa diet, respectively. Groups 3 and 4 were injected with DEN at 2 and 4 weeks, and fed with standard and cocoa diet, respectively. Group 5 was treated with DEN, received the standard diet for 4 weeks and then it was replaced by the cocoa-diet. The cocoa-rich diet prevented the reduction of hepatic glutathione concentration and catalase and GPx activities in DEN-injected rats, and diminished protein carbonyl content, caspase-3 activity, p-AKT and p-JNK levels, and increased GST activity. Cocoa administration did not abrogate the DEN-induced body weight loss, the increased levels of hepatic-specific enzymes and LDH. These results suggested that cocoa-rich diet attenuates the DEN-induced liver injury.

Cocoa-rich diet attenuates N-nitrosodiethylamine-induced liver injury in rats

243rd National Meeting (2012)

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