Hydroacylation is an atom economical and efficient method for preparing ketones from readily available aldehyde and olefin precursors.  In this poster, we report the rhodium-catalyzed intermolecular hydroacylation of allylic and homoallylic alcohols to give aldol and homoaldol products, respectively.  Our method is also applicable to hydroacylation of 2-hydroxystyrenes.  This reaction is promoted by a phosphinite co-catalyst that reversibly binds both the substrate and metal to promote the olefin functionalization.

Phosphinite-promoted hydroacylation as an approach to both aldol and homoaldol products

243rd National Meeting (2012)

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