The association of metal ions with proteinaceous aggregates containing amyloid-� (A�) peptides found in Alzheimer's disease (AD) may be related to neurodegeneration and cognitive deficits of the disease. Metal ions such as Cu(II) and Zn(II) are able to bind to the peptides in vitro thereby accelerating aggregation and facilitating the production of reactive oxygen species (ROS). The direct contribution of metal ions in AD pathogenesis remains controversial, however, validating the recent efforts to identify small molecules to interrogate these processes. In addition to recently reported synthetic small molecules, rational screening and selection of naturally occurring molecules could be considered. The present study demonstrates that the anti-amyloidogenic, metal chelation, and antioxidant properties of flavonoids can work concurrently to modulate the aggregation and neurotoxicity of A� in the presence of metal ions in vitro, which may uncover new insights in the involvement of metal ions in A�-related events of AD.

Exploring the reactivity of flavonoids toward metal-associated amyloid-<i>β</i> species in Alzheimer's disease

243rd National Meeting (2012)

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Exploring the reactivity of flavonoids toward metal-associated amyloid-β species in Alzheimer's disease