Carbon monoxide is a biologically relevant, endogenously produced small molecule.  Studies have shown CO to promote many physiological effects, such as stimulating wound healing, preventing ischemia/reperfusion injury, and preventing organ graft rejection.  Here is discussed a novel class of photoactive CO releasing moieties (photoCORMs) based on rhenium (I) diimine tricarbonyl complexes.  These complexes are an attractive option for CO delivery in that they serve as benign reservoirs for CO until it is needed; at which point, the affected area can be irradiated with light of an appropriate wavelength, releasing CO.  This delivery mode provides exceptional control over the location, timing and dosage of CO in biological systems.  The synthesis, characterization and photochemistry of these complexes will be presented.

Photoactive CO releasing moieties (photoCORMs) based on rhenium diimine carbonyls for use in therapeutic applications

243rd National Meeting (2012)

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