Fluorinated analogues of nitrogen containing biologically active compounds are regarded as tools of relevant interest for pharmaceutical research. Consequently the discovery of new methods to access fluoroamines remains a major challenge in synthetic chemistry.Based on superelectrophilic activation,1 we converted a range of unsaturated amines and sulfonamides to fluorinated analogues via novel reactions in superacid HF/SbF5.2-6  Some of the synthesized fluorinated derivatives show inhibitory activities against carbonic anhydrases.7 This work opens new possibilities for the direct and effective preparation of fluorinated nitrogen compounds of high synthetic and biological values.References: G. A. Olah, D. Klumpp, Superelectrophiles and their chemistry, John Wiley and Sons: New-York, 2008.S. Thibaudeau, A. Martin-Mingot, M-P. Jouannetaud,O. Karam, F. Zunino Chem. Commun. (2007) 3198-3200.E. Vardelle,D. Gamba-Sanchez, A. Martin-Mingot, M-P. Jouannetaud, S. Thibaudeau, J. Marrot Chem. Commun. (2008) 1473-1475.F. Liu, A. Martin-Mingot, M-P. Jouannetaud, O. Karam, S. Thibaudeau, Org. Biomol. Chem. 7 (2009) 4789-4797.. E. Vardelle, A. Martin-Mingot, M-P. Jouannetaud, C. Bachmann, J. Marrot, S. Thibaudeau, J. Org. Chem. 74 (2009) 6025-6034.F. Liu, A. Martin-Mingot, M-P. Jouannetaud, F. Zunino, S. Thibaudeau, Org. Lett. 12 (2010) 868-871. Unpublished results

Synthesis of fluorinated nitrogen-containing compounds in superacid HF/SbF<sub>5</sub>

243rd National Meeting (2012)

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Synthesis of fluorinated nitrogen-containing compounds in superacid HF/SbF5

Synthesis of fluorinated nitrogen-containing compounds in superacid HF/SbF₅