Recent works report the antibacterial activity of doxycycline loaded Chitosan/Poly(L-lactic acid)/Polycaprolactone blend film against Staphylococcus aureus and Escherichia coli, as model Gram-positive and Gram-negative bacteria, respectively. The blended film was studied as a model device to deliver drug to targeted human organ which in this case was the skin with opened wound. PLA was synthesized by direct polycondensation then blended with polycaprolactone to enhance impact resistance. Later, the PLA/PCL composite was mixed with chitosan solution before casting into the film by solvent evaporation technique. Film properties and the delivery rate of doxycycline were investigated. The loaded chitosan/Poly(L-lactic acid)/Polycaprolactone film delivery study gave a superior release rate which approached almost 100% doxycycline loaded. In vitro antibacterial test of the doxycycline loaded film demonstrated the ability of the film to inhibit common bacterial growth at the initial stage while the virgin chitosan film only prolonged the growth of both bacteria tested.

Antibacterial activity of doxycycline loaded chitosan/poly(L-lactic acid)/polycaprolactone blend for wound dressing device

243rd National Meeting (2012)

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