Enantiopure chemicals are of great importance in pharmaceutics. Since the preparation to obtain those is often economic deficient, enantioseparation is required. Besides the elaborate and expensive chromatography and crystallization techniques, chiral membranes are known to be effective therein. In order to circumvent the specific membrane development for a certain compound in a suited solvent, we seized good experiences with a new class of chiral separating membranes that are applicable for various solvents and therefore potentially many substrates. Those membranes are based on nanophasic, amphiphilic polymer conetworks (APCN) featuring a chiral phase of poly((R),(S)-N-(1-hydroxy-butan-2-yl)acrylamide) (P-(R),(S)-HBA) and a non-chiral polydimethylsiloxane (PDMS) phase. To achieve a facile and cheap preparation of chiral membranes, we thought of utilizing the vast intrinsic interface containing structures of a similar Poly (acrylic acid)-co-(hydroxyethyl acrylate)-l-Poly (dimethylsiloxane) (PAA/PHEA-l-PDMS) conetwork membrane by chiral impregnation in order to demonstrate that the APCNs can subsequently be successfully utilized as chiral separation membranes.

Impregnated amphiphilic polymer conetwork membranes for chiral separation

243rd National Meeting (2012)

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