We have previously demonstrated the constitutional self-assembly of pyrimidine ribonucleotides from mixtures of simple building blocks, and we are now exploring similar 'systems chemistry' approaches to the purine ribonucleotides, and ways of assembling RNA from these ribonucleotides with regiocontrol of the internucleotide phosphodiester linkage. Success or not in these ventures will go some way to answering the question posed in the title to this presentation.

RNA – prebiotic product, or biotic invention?

243rd National Meeting (2012)

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