p-Aminobenzoic acid esters and polyamines are known to be involved in cell damage and yet are also useful in the treatment of seizures and epilepsy. They play the neuroprotective role when administered in specific concentrations. This contradicting but important nature of these compounds interested us in exploring the synthesis of such compounds. Attempted synthesis of cyclohexyl ester of p-aminobenzoic acid by Fischer Esterification under thermal heating led to a mixture of products and the product isolation was troublesome. However, under micro waves, a pure single product was achieved. Synthesis of aromatic monoamines and polyamines via the nucleophylic aromatic substitution reactions are quite cumbersome and involve longer reaction times under thermal heating. Micro wave irradiation of 2,4-dinitrobromobenzene by ammonia, aniline and hexane diamine respectively gave the corresponding aromatic amines in good yields with maximum purity. The compounds are characterized by IR and NMR. The method of synthesis and characterizations are discussed.

Investigating the synthesis of aromatic esters and amines of medicinal values under micro waves

243rd National Meeting (2012)

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