Over the last decade, palladium catalyzed coupling reactions have become increasingly utilized in organic synthesis for the formation of carbon-carbon or carbon-heteroatom bonds. New approaches are being pursued to minimize the use of traditional organic solvents, develop recyclable catalysts, and to limit the overall production of environmentally harmful waste material. One way that this can be achieved is through the synthesis of water soluble phosphine ligands by the addition of anionic groups for catalysis in water or biphasic systems. Our design of these water soluble ligands is based on the need for steric bulk and electron richness to promote the catalytic cycle. The design also utilizes the flexible coordinating ability of a benzyl moiety which may contain additional electron donating substituents. Once we have synthesized these ligands, we will be studying their activity in palladium-catalyzed coupling reactions. Further studies will help to elucidate the role of the different groups on the ligand in promoting catalysis.

Synthesis of new water soluble phosphine ligands for application in environmentally benign syntheses

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.