Conjugate acid-base pairs are compounds that differ by one proton.  Hydrogen bonds formed between these pairs are well known for their unusual features, such as very short bond distance and exceptional strength.[1]  In the current literature extra attention has remunerated on obtaining new solid-state structures of Active Pharmaceutical Ingredients (APIs ) because of fundamental, practical, and legal interests.[2]  However, structure design based on these interactions in APIs have generally not been well explored in the primary literature.In this context, we have investigated potential problems in preventing the design of crystal structures based on the strong interactions between conjugate acid and base, using two well known APIs, i.e., Naproxen and Nicotinamide and the results obtained were discussed in this work. [1] J. Clare Speakman, in Structure and Bonding, Vol. 12, Springer Berlin / Heidelberg, 1972 , pp. 141-199.[2] O. Almarsson, M. J. Zaworotko, Chem. Commun. 2004 , 1889-1896.

Design and synthesis of solid state structures with conjugate acid-base pair interactions

243rd National Meeting (2012)

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