Torsion balances are useful for measuring CH-pi interactions in a single molecule.  Our preliminary data1 show that replacing the methano (NCH2N) bridgehead with an ethano (NCH2CH2N) bridgehead affects the conformational equilibrium of the torsion balance, and suggests the CH-pi interaction distance is decreased.  This talk will discuss our efforts to experimentally determine the relationship between CH-pi interaction strength and distance using the torsion balance approach.    1 Bhayana, B.; Ams, M. R.  J. Org. Chem.  2011 , 76, 3594-3596

Effect of diazocine bridgehead modification on the folding of the Wilcox molecular torsion balance

243rd National Meeting (2012)

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