Echinopine A and B are sesquiterpenes isolated in 2008 from the roots of Echinops spinosus, a common North African plant. An unprecedented structure featuring a [3,5,5,7] tetracyclic system has been proposed. These targets constitute a challenge for a total synthesis that could confirm their intriguing structure and investigate their biological activity. The first total synthesis of has been reported in 2009, confirming the accuracy of the unusual structure. Our concomitant investigations led to one formal and two total syntheses.

Total synthesis of echinopines A and B

243rd National Meeting (2012)

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