In the present study, antibacterial properties of completely green synthesized dextrose encapsulated GNPs were investigated against both Gram-negative and Gram positive bacteria. Experiments were performed to analyze the growth, morphology and the ultra-structural changes in bacteria. GNPs found to have significant dose dependent antibacterial activity which was directly proportional to increase in the size of nanoparticles. The microbial assays showed the GNPs to be bacteriostatic as well as bactericidal. This special dextrose encapsulated GNPs exert their bactericidal action via disrupting the bacterial cell membrane causing leakage of cytoplasmic content. The cytotoxicity studies suggest the GNPs to be non-toxic towards mammalian cells proving the nanoparticles to be biocompatible. Results of this study clearly suggest that dextrose encapsulated GNPs can be used as a potent antibacterial agent against wide range of bacteria to control and prevent various infections or diseases caused by them.

Size dependent antimicrobial activity of sugar encapsulated gold nanoparticles

243rd National Meeting (2012)

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