We report on the synthesis and characterization of a series of fluorophores, which potentially could be used as photodynamic therapy agents. These fluorophores were designed to have a pH responsive action that may better target cancer cells that are known to be more acidic. The fluorophores consist of brominated analogs of rhodamine regulated by a spiro-cyclic structure that is responsive to environmental pH. It is our long term goal that this PDT agent could simultaneously be used for medical imaging and cancer treatment.

Synthetic efforts towards a selective photodynamic therapy agent

243rd National Meeting (2012)

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