Organic azides, synthesized from alkyl bromides, meta-fluorobenzyl bromide or glycidol by reaction with sodium azide, were allowed to react with meta-fluoroalkynylbenzene or a 3-aryl-2-alkynyl-carboxylic acid in the presence of copper sulfate pentahydrate and sodium ascorbate (Vitamin C) in a 1:1 tert-butyl alcohol/water solution. Decarboxylation of the 3-aryl-2-alkynylcarboxylic acids occurred under the conditions necessary to form 1,2,3-disubstituted triazoles by click chemistry. Compounds were purified from an ethanol/water solvent pair and analyzed using TLC, NMR, IR, and techniques. Data for several of the triazole derivatives are presented.

Synthesis of disubstituted 1,2,3-triazoles via copper(I)-catalyzed cycloaddition

243rd National Meeting (2012)

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