Benzodiazepines are central nervous system (CNS) depressants prescribed for treating anxiety, tension, muscle spasms, alcohol withdrawal, and insomnia.  The 1,4-benzodiazepines are the most common class, and are exemplified by the drug, diazepam, trade name Valium.  We are attempting to develop a new approach to synthesizing specific diaziridines that may provide a more robust route into the lesser known 2,4-benzodiazepine ring system.  The new approach attempts to exploit the reaction between certain silylated diaziridines with 1,2-diaroyl dichlorides.  The results of the progress of this investigation are the subject of this poster.

Progress towards the synthesis of novel 1-aryl-1-trimethylsilyl-1<i>H</i>-diazirino[1,2-<i>b</i>]phthalazine-3,8-diones

243rd National Meeting (2012)

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Progress towards the synthesis of novel 1-aryl-1-trimethylsilyl-1H-diazirino[1,2-b]phthalazine-3,8-diones