Pyrazole and pyrazolones are five membered heterocyclic compounds that have many biological and synthetic uses. �- ketoesters or �-diketones were combined with hydrazines to generate pyrazole/ pyrazolone compounds using three different conditions: thermal, PSSA (polystyrene supported sulfuric acid), and MW (microwave). Following purification, 1H NMR was used to verify that each reaction condition generated the same product. The isolated pyrazole and pyrazolone compounds have been further analyzed as inhibitors of Glycine max (soybean) lipoxidase in a subsequent biochemistry course.

Pyrazole and pyrazolone synthesis as an undergraduate laboratory experiment

243rd National Meeting (2012)

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