The ?-lactam or 2-oxopyrrolidine structure is widely found in medicinal chemistry and is an important structural motif in many biologically active compounds.  The rapid assembly of this valuable structure has been the subject of recent activity. In this poster we present the results of our efforts to develop an efficient preparation of �-hydroxy-?-lactams based on a-amino acids.  Specifically through the application of a nickel-catalyzed Reformatsky reaction between a-bromoesters and ketones derived from N-protected a-amino acids as the key carbon-carbon bond-forming step. 

β-Hydroxy-γ-lactams: A Reformatsky approach

243rd National Meeting (2012)

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