Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) and is commonly employed in the treatment of inflammatory diseases. The use of this NSAID can lead to several adverse effects, thus increasing the need of appropriate devices to reduce such undesired effects.In this work, bovine serum albumin-piroxicam (BSA-piroxicam) and human serum albumin-piroxicam (HSA-piroxicam)-piroxicam microspheres were sonochemically prepared and characterized. The results demonstrated that the use of stabilizers led to an improvement of formulation characteristics, including smaller size, lower polydispersity index, higher entrapment efficiency and higher stability. The release kinetics of these microspheres was determined in presence of protease, indicating an anomalous drug transport mechanism (diffusion and protein degradation). These proteinaceous devices did not show cytotoxicity against human skin fibroblasts in vitro, for range concentrations below to 300 mg.L-1, greatly supporting their potential application in the treatment of inflammatory diseases.

Protein microspheres as suitable devices for piroxicam release

243rd National Meeting (2012)

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