Nanoparticles are of interest in oncology for delivery of drugs or vaccines or as agents for imaging or direct therapeutic stimulation in tumors.  However, achieving the full potential of nanomaterials in cancer diagnosis and treatment will require a better understanding of how to control nanoparticle-cell interactions.  We have been exploring how surface chemistry of nanoparticles and particle functionalization influences interactions with the cell membrane, internalization of nanoparticles, and biological responses to nanoparticles in vitro and in vivo.  Examples of two strategies for mediating cell-nanoparticle interactions will be presented, one based on modulating the physical chemistry of nanoparticle-cell interactions via the design of organic ligand-protected gold nanoparticles, and a second based on bioconjugation strategies to anchor nanoparticles to cell membranes in ways that either promote or prevent nanoparticle internalization.

Engineering nanoparticle interactions with cells via synergies in biochemistry and physical chemistry

243rd National Meeting (2012)

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