A major challenge in PET radiotracer development is to identify efficient methods for rapidly incorporating cyclotron-produced [18F]fluoride ion into organic molecules. A major cost in the development of new radiotracers is the time spent in the determination of the optimum labeling conditions.This presentation will describe research on the preparation of F-18 radiotracers using the NanoTek LF microfluidic system and will cover the advantages and limitations that must be considered when preparing radiotracers using a microfluidic capillary based system and the methodology of rapidly determing of the optimum labeling conditions.By operating reactions at significantly elevated temperatures and pressures and using of a wide range of solvents, it has been shown that reactions may be accelerated and the post reaction processing may be simplified when compared to conventional synthesizers.

Microfluidic flow chemistry synthesis of F-18 radiotracers at elevated temperatures and pressures

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.