We report a one-pot synthesis method to prepare water-soluble magnetite nanoparticles. Polyamines are chosen as reaction medium for the iron precursors and facilitate the nucleation and subsequent growth of the nanoparticles. By controlling the heating rate, variable sized Fe3O4 nanoparticles with narrow size distribution can be prepared. Polyamines coated nanoparticles are stable and highly positive charged in aqueous solution. The free amine functional groups are readily available for the attachment of small gold nanocrystal or CdSe/ZnS core-shell quantum dots onto the surface of magnetite nanoparticles. The conjugation of biotin to the nanoparticles via amine group enable the polyamine coated nanoparticles to specifically separate streptavidin from multiple proteins. Their low non-specific interaction, reactive surface functional groups, stable protective ligand shell and the high saturation magnetization make amine functionalized nanoparticles promising candidate agents for bioseparation and other biomedical applications.

Polyamines as both solvents and stabilizing agents to prepare water-soluble Fe<sub>3</sub>O<sub>4</sub> nanoparticles with reactive surface functionalities

243rd National Meeting (2012)

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Polyamines as both solvents and stabilizing agents to prepare water-soluble Fe3O4 nanoparticles with reactive surface functionalities

Polyamines as both solvents and stabilizing agents to prepare water-soluble Fe₃O₄ nanoparticles with reactive surface functionalities