Novel turn-off fluorescent coumarin-functionalized sensors for the nerve gas simulant diethylchlorophosphate (DCP) were designed and synthesized. The compounds exhibit fluorescence around 500nm which is quenched by DCP. This results from the DCP-induced increase in charge density and the rigidity of the sensor molecules. 1H NMR results confirm the binding mode to be via the imine nitrogen. These coumarin derivatives are the basis for rapid, selective and sensitive colorimetric DCP chemosensors in acetonitrile.              

Novel turn-off nerve gas sensors based on coumarin Schiff base derivatives

243rd National Meeting (2012)

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