a-Ketoglutarate (also called oxo-glutarate) is an important nitrogen acceptor in metabolism. It is produced by oxidative deamination of glutamate or reductive carboxylation of succinate. In this study, we developed a noble biotransformation reactor for a-ketoglutarate production using enzyme aggregated monolith reactor. L-glutamic dehydrogenase was aggregated on the surface of nanofiber and used for the the development of monolith reactor. The a-ketoglutarate was produced from glutamate with monolith reactor and its conversion was changed with residence time. SEM images of glutamic dehydrogenase aggregated monolith reactor

Use of monolith reactor for α-ketoglutarate production with glutamic dehydrogenase

243rd National Meeting (2012)

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