8,4'''-dieckol is a natural product that has been isolated from brown alga Ecklonia cava. This polyphenolic compound is a phlorotannin derivative with a broad range of bioactivities. Human immunodeficiency virus type-1 (HIV-1) inhibitory activity of 8,4'''-dieckol was tested and the results indicated that 8,4'''-dieckol inhibited HIV-1 induced syncytia formation, lytic effects and viral p24 antigen production at non-cytotoxic concentrations. Furthermore, it was found that 8,4'''-dieckol selectively inhibited the activity of HIV-1 reverse trancriptase (RT) enzyme with 91% inhibition ratio at the concentration of 50 �M. HIV-1 entry was also inhibited by 8,4'''-dieckol. According to data from this study, 8,4'''-dieckol is an effective compound against HIV-1 with high therapeutic index and after further studies on mechanism of inhibition it might be used as a drug candidate for development of new generation therapeutic agents.

Anti-HIV-1 activity of phlorotannin derivative 8,4'''-dieckol from <i>Ecklonia cava</i>

243rd National Meeting (2012)

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Anti-HIV-1 activity of phlorotannin derivative 8,4'''-dieckol from Ecklonia cava