Bismuth subsalicylate is the active pharmaceutical ingredient in stomach relief suspensions.  Dissolution testing was performed for both the bismuth and the salicylic acid.  Each dissolution test used 900 mL of deaerated media at 37�C. Bismuth was not soluble in the media used in this study.  However, in deionized water, salicylic acid becomes more than 50% soluble in 10 minutes.  To discern different brands of stomach relief suspensions, variations in the paddle speed, media and sample size for the dissolution test were investigated.  As sample size increased, filtering capability decreased.  More salicylic acid is soluble in less time when using 50 RPMs as opposed to 100 RPMs.

Release characteristics of salicylic acid and bismuth from stomach relief suspensions

243rd National Meeting (2012)

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