Several new acetylpyrazine thiosemicarbazone ligands have been synthesized in our laboratory and characterized by 1H NMR spectrometry. These new compounds have been shown to ligate several transition metals such as Pd2+, In3+, and importantly Ga3+ in a tridentate fashion. These compounds were tested for antimicrobial activity by determining the minimum inhibitory concentrations against four bacteria (Bacillus subtilis, Saphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), two yeast (Canida albicans and Sacchromyces cervisiae), and one mold (Aspergillus niger). The results show that these compounds are highly active inhibitors across this broad spectrum of microorganisms, even at low concentrations.

Synthesis and antimicrobial studies of acetylpyrazine-thiosemicarbazone ligands and complexes of Pd2+, In3+, And Ga3+

243rd National Meeting (2012)

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