The reversible self-assembly process involving an oligomer of amyloid-�1-40 peptide was examined on a gold colloidal suspension of 20, 30, and 40 nanometer particles at temperatures ranging from 5 to 45 �C. As the pH was externally changed repetitively between pH 4 and 10, a reversible assembly was observed for an entire temperature range for 20 nanometer gold colloid. However, 30 and 40 nanometer colloids support the reversible process only at lower temperatures than 18 �C and 6 �C, respectively. Even when temperature was increased in the middle of the self-assembly process, the reversible process was maintained. This specific size and temperature dependence in relation to reversible color change strongly suggests that the initial conformation of the amyloid-� under the surface potential drives the entire reversible assembly process.

Temperature dependence of self-assembly of amyloid beta peptide on a nanoscale gold colloidal surface

243rd National Meeting (2012)

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