With an aim to stably produce an oligomer form of amyloid beta (a key intermediate of fibrillogenesis that eventually leads to Alzheimer's disease), the surface of gold colloids were functionalized with nitro-, phenyl-, chloro-, and methoxy-dibenzyloxy disulfide. The molecular interactions were then investigated in a dimethyl sulfoxide environment. The transition of color change was observed at pHo as the pH value was externally lowered. The pHo values were dependent of each substituent of dibenzyloxy disulfide compounds as measured by amount of disulfide absorption on the colloidal surface.  The trend of pHo exhibited a parabolic relationship as a function of F-value (Swain-Lupton Field constant). Functionalization of gold colloidal surface with methoxy-dibenzyloxy disulfide achieved larger amplitude in repetitive peak shift between pH 4 and 10 implying a formation of an oligomer under the reversible process.

Self-assembly of amyloid beta peptide over dialkoxy disulfide functionalized nano gold colloidal particles

243rd National Meeting (2012)

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