I will present new results where we use nanofabricated substrates that impose curvature to create dynamic sorting patterns of lipid domains that resemble the pixilated patterns of integrated circuits.  A square lattice of hemisphere-like features, �bumps�, were fabricated by electron beam lithography of PMMA coated silicon wafers.  A lipid multibilayer stack of DPPC: DOPC: cholesterol was deposited on the nanofabricated substrates using spin coating.  This composition displays liquid-ordered (Lo)/liquid disordered (Ld) coexistence. The smallest 200 nm lattice sorted Lo phase into distinct interconnected networks of lines and rectangular shapes.  The interconnectedness of the domain pattern decreased as the lattice spacing increased.  Isolated circular domains, confined to one unit cell of the lattice, emerged in the pattern.  These are essentially the �pixels�, or smallest addressable elements, and it will be shown that dynamic patterns of Lo phase are formed through placement and movement of these domain pixels.

Patterning of nanometer-scale domains in lipid bilayers: Membrane "circuits"

243rd National Meeting (2012)

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