We have implemented the disaccharide trehalose as an agent to protect particle surfaces from protein opsonization and to preserve assembled structures against destruction upon dehydration. This strategy has been explored with regard to both lipid and polymer nanoparticles for use in delivery.  Sugar chemistry developed to provide effective particle conjugation will be discussed.

Stabilized surface glycosylated lipid and polymer nanoparticles for systemic delivery

243rd National Meeting (2012)

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