Click chemistry was used for the post-functionalization of hydrophilic polymer brushes. The polymer brushes were random copolymers of AzPMA (azidopropyl methacrylate), a functional monomer with a pendent azo group, and oligoethylene glycol methyl ether methacrylate (mPEGMA) with varying ethylene oxide chain lengths, which enabled control over the hydrophilicity and functional group density in the copolymer. Subsequent post-functionalization of homo and copolymer brushes was demonstrated by appending an alkyne-modified dye to AzPMA via click reactions. Kinetic studies showed that the modification of surface-grafted homo/copolymer brushes was fast (> 60% conversion in 1 min) irrespective of the copolymer composition. In the case of high molecular weight water soluble alkynes, surface-grafted copolymers with highest amount of hydrophilic monomer (mPEGMA) gave the highest degree of immobilization, which indicates its potential application in bioconjugation.

Polymerization of azidomethacrylates from surfaces and their elaboration via click chemistry

243rd National Meeting (2012)

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