Ionic Liquids (ILs, salts that melt below 100 �C) loaded on silica have been studied for gas phase reactions, but they have not been used in solution due to the leaching properties of the ILs and the deactivation of the catalyst. One area where the �Supported Ionic Liquid Phase� (SILP) strategy would be a tremendous advantage would be in the loading of ILs that are intended and necessarily leached in order to carry out their functions, as is the case of ILs of Active Pharmaceutical Ingredients (APIs). We have found that IL-APIs are readily loaded and leached from silica, giving to the material a few advantages including the ability to deliver these liquid salt drugs in solid form as free flowing powders. This presentation will discuss the loading, leaching, and favorable physical and chemical properties exhibited by these IL-APIs in solid form.

Ionic liquid-active pharmaceutical ingredients loaded on silica: Solids handling for liquid pharmaceutical forms

243rd National Meeting (2012)

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