Based on the proven utility of pharmacological inhibitors to dissect complex cellular processes, we have isolated compounds that inhibit cellulose biosynthesis by chemical library screening and via chemical profiling of microorganisms that colonize and exploit plant cells. From this collection of inhibitors, we delineate three distinct classes of inhibition mechanism and use these phenotypes to learn about the insertion, guidance and regulation of cellulose synthesis.

Chemical genetic dissection of cellulose biosynthesis

243rd National Meeting (2012)

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