Rigorous examination of reactions of organic azides with well-defined copper(I)-acetylides stabilized by an NHC ligand unequivocally established the intermediacy of dinuclear copper complexes within the CuAAC.  The roles of two copper centers were delineated using isotopically enriched copper(63) catalysts, demonstrating their equivalency during the course of the reaction and the true step-wise nature of the C�N bond-forming events. New elementary steps within the CuAAC were identified expanding the reach of catalytic cycloadditions.

Mechanistic insights into CuAAC using well-defined copper(I)-acetylides

243rd National Meeting (2012)

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