Quinolines have been long known to embody a range of important pharmacological and physical properties, from antimalarial and anti-inflammatory, to nano and meso structures with enhanced photonic and electronic properties. A facile one-pot strategy to rapidly access alkyl and/or aryl multi-substituted quinoline derivatives in high yields from commercially available starting materials has been developed. This catalytic process proceeds efficiently in air, tolerates up to 10 equivalents water, and is operable in a variety of solvents, creating a methodology with high atom economy and catalytic efficiency.

Efficient one-pot synthesis of substituted quinolines from commercially-available starting materials

243rd National Meeting (2012)

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