While an important method for accessing nitrogen-containing building blocks, research in the area of imine alkynylation is dominated by the alkynylation of aldimines to construct propargylamines. The few examples of ketimine alkynylation in literature require the use of multiple catalysts or stoichiometric amounts of zinc and base, each providing products of limited scope. We have developed a catalytic one-pot reaction to yield ketone-derived propargylamines to provide fully substituted nitrogen-bearing carbon centers. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/12284_abstract_-_version_3.jpg' alt='' />

Catalytic route to ketone-derived propargylamines via commercially available materials

243rd National Meeting (2012)

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