Supramolecular self-assembly has emerged over the past two decades as a strategy to create new materials.  One of the important directions in this field is the development of one-dimensional assemblies that can be described as �ordered supramolecular polymers.�  These structures can also be integrated into more complex hierarchical structures with covalent polymers or inorganic nanostructures and one of the compelling directions in this field is the design of novel biological functions.  Our laboratory has developed supramolecular nanoscale filaments based on peptide amphiphiles with the capacity to signal cells and with great potential as therapies for regenerative medicine and cancer.  This lecture will describe the integration of biological signaling with electrical stimuli to signal and pace heart cells and also the use of fields to craft cell-like objects in supramolecular systems.  The lecture will also describe the broad use of photo-responsive and enzyme-responsive systems to control cell signaling and drug delivery.

Supramolecular systems responsive to light, enzymes, and electric fields

243rd National Meeting (2012)

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